What is BioEnhanced™ Na-RLA Stabilized R-Lipoic Acid ?
Alpha-lipoic acid comes in two forms, designated as “R-lipoic acid” and “S-lipoic acid.” R- and S- lipoic acid are enantiomer isomers––molecules that appear as mirror images of each other. R-lipoic acid is naturally synthesized by humans, animals, and plants. S-lipoic acid is formed during chemical synthesis of alpha-lipoic acid, producing a “racemic” mixture of the two enantiomers that is often used in clinical studies on alpha-lipoic acid. Pharmacokinetic studies have shown that R-lipoic acid is more bioavailable than the S- form.1 For example, following single oral doses of 50 to 600 mg of racemic LA, maximum serum levels of the R- form were 40 to 50% higher than the S- lipoic form.
Best Stabilized R-Lipoic Acid contains BioEnhanced™ Na-RLA, the sodium salt of R-Lipoic acid (RLA). Pure RLA is a very unstable molecule that has a tendency to polymerize with exposure to heat, light, and moisture. This presents problems for those wishing to supplement with RLA, since any of these conditions can lead to deactivation of the beneficial activity of alpha-lipoic acid. Unlike pure RLA, BioEnhanced™ Na-RLA is a stabilized form of RLA that won’t degrade at high temperatures. By taking the sodium salt of RLA, its solubility is increased and it has an improved dissolution in the body. It is more bioavailable than regular RLA and has no solvent residues.
Note regarding sodium: The RLA in this product is stabilized with Na (sodium). However, one serving of this product contains less than 1% of the Daily Value for sodium, an insignificant contribution to dietary sources. Research suggests that sodium may impact blood pressure in some individuals only when it is consumed as sodium chloride (NaCl, table salt) and not in other forms. The sodium in this product is unlikely to affect blood pressure levels.
Why include D-Biotin ?
Best Stabilized R-Lipoic Acid includes optically pure D-Biotin, the natural form of biotin. D-Biotin is a water-soluble vitamin and member of the vitamin B-complex that aids in the utilization of other B-complex vitamins. Integral to many of the activities of enzymes in the human body, D-biotin is necessary for the breakdown and conversion of fatty acids and carbohydrates into energy, allowing for the production of fats and excretion of protein breakdown products. Long-term administration of lipoic acid can lower the activities of the biotin-dependent enzymes pyruvate carboxylase and beta-methylcrotonyl-CoA carboxylase by competing with biotin.4 Supplementing with LA may thus increase the body's requirements for this vitamin.